Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19
Antonin Trimaille
(1)
,
Sophie Ribeyrolles
(2)
,
Charles Fauvel
(3)
,
Corentin Chaumont
(3)
,
Orianne Weizman
(4)
,
Thibaut Pommier
(5)
,
Joffrey Cellier
(6)
,
Laura Geneste
(7)
,
Vassili Panagides
(8)
,
Wassima Marsou
(9, 10)
,
Antoine Deney
(11)
,
Sabir Attou
(12)
,
Thomas Delmotte
(13)
,
Pascale Chemaly
(14)
,
Clément Karsenty
(11)
,
Gauthier Giordano
(4)
,
Alexandre Gautier
(14)
,
Pierre Guilleminot
(5)
,
Audrey Sagnard
(5)
,
Julie Pastier
(5)
,
Baptiste Duceau
(15)
,
Willy Sutter
(6, 15)
,
Victor Waldmann
(6, 15)
,
Théo Pezel
(16)
,
Delphine Mika
(17)
,
Ariel Cohen
(18)
,
Guillaume Bonnet
(15, 19)
1
CHU Strasbourg -
Centre Hospitalier Universitaire [Strasbourg]
2 IMM - Institut Mutualiste de Montsouris
3 CHU Rouen
4 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
5 CHU Dijon
6 HEGP - Hôpital Européen Georges Pompidou [APHP]
7 CHU Amiens-Picardie
8 CHU Marseille
9 UCL - Université catholique de Lille
10 GHICL - Groupement des Hôpitaux de l'Institut Catholique de Lille
11 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
12 CHU Caen
13 Hôpital universitaire Robert Debré [Reims]
14 ICPS - Institut Cardiovasculaire Paris Sud
15 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
16 Hôpital Lariboisière-Fernand-Widal [APHP]
17 CARPAT (UMRS1180) - Signalisation et physiopathologie cardiovasculaire
18 CHU Saint-Antoine [AP-HP]
19 Hôpital Haut-Lévêque [CHU Bordeaux]
2 IMM - Institut Mutualiste de Montsouris
3 CHU Rouen
4 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
5 CHU Dijon
6 HEGP - Hôpital Européen Georges Pompidou [APHP]
7 CHU Amiens-Picardie
8 CHU Marseille
9 UCL - Université catholique de Lille
10 GHICL - Groupement des Hôpitaux de l'Institut Catholique de Lille
11 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
12 CHU Caen
13 Hôpital universitaire Robert Debré [Reims]
14 ICPS - Institut Cardiovasculaire Paris Sud
15 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
16 Hôpital Lariboisière-Fernand-Widal [APHP]
17 CARPAT (UMRS1180) - Signalisation et physiopathologie cardiovasculaire
18 CHU Saint-Antoine [AP-HP]
19 Hôpital Haut-Lévêque [CHU Bordeaux]
Antonin Trimaille
- Fonction : Auteur
- PersonId : 1191359
- ORCID : 0000-0001-9279-4220
Antoine Deney
- Fonction : Auteur
- PersonId : 806538
- ORCID : 0000-0003-0880-7506
Pascale Chemaly
- Fonction : Auteur
- PersonId : 1243264
- ORCID : 0000-0002-3021-7388
Clément Karsenty
- Fonction : Auteur
- PersonId : 804549
- ORCID : 0000-0002-3303-5854
- IdRef : 19786919X
Alexandre Gautier
- Fonction : Auteur
- PersonId : 1243265
- ORCID : 0000-0003-4378-299X
Guillaume Bonnet
- Fonction : Auteur
- PersonId : 1243266
- ORCID : 0000-0002-3027-1771
Résumé
Although 18–45-year-old (y-o) patients represent a significant proportion of patients hospitalized for COVID-19, data concerning the young population remain scarce. The Critical COVID France (CCF) study was an observational study including consecutive patients hospitalized for COVID-19 in 24 centers between 26 February and 20 April 2020. The primary composite outcome included transfer to the intensive care unit (ICU) or in-hospital death. Secondary outcomes were cardiovascular (CV) complications. Among 2868 patients, 321 (11.2%) patients were in the 18–45-y-o range. In comparison with older patients, young patients were more likely to have class 2 obesity and less likely to have hypertension, diabetes and dyslipidemia. The primary outcome occurred less frequently in 18–45-y-o patients in comparison with patients > 45 years old (y/o) (16.8% vs. 30.7%, p < 0.001). The 18–45-y-o patients presented with pericarditis (2.2% vs. 0.5%, p = 0.003) and myocarditis (2.5% vs. 0.6%, p = 0.002) more frequently than patients >45 y/o. Acute heart failure occurred less frequently in 18–45-y-o patients (0.9% vs. 7.2%, p < 0.001), while thrombotic complications were similar in young and older patients. Whereas both transfer to the ICU and in-hospital death occurred less frequently in young patients, COVID-19 seemed to have a particular CV impact in this population.