Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue BMC Cancer Année : 2023

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

1 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
2 EREN [CRESS - U1153 / UMR_A 1125] - Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle
3 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
4 University of Naples Federico II = Università degli studi di Napoli Federico II
5 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
6 NKUA - National and Kapodistrian University of Athens
7 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
8 Umeå University
9 UiT - The Arctic University of Norway [Tromsø, Norway]
10 UCPH - University of Copenhagen = Københavns Universitet
11 Danish Cancer Society Research Center
12 Imperial College London
13 Lund University
14 DIfE - German Institute of Human Nutrition Potsdam-Rehbrücke
15 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
16 Aarhus University [Aarhus]
17 CESP - Centre de recherche en épidémiologie et santé des populations
18 University Medical Center [Utrecht]
19 Nuffield Department of Population Health [Oxford]
20 University of Melbourne
21 CAM - University of Cambridge [UK]
22 Azienda Ospedalerio - Universitaria Città della Salute e della Scienza di Torino = University Hospital Città della Salute e della Scienza di Torino
23 IRCCS Istituto Nazionale dei Tumori [Milano]
Annika Idahl
  • Fonction : Auteur
Emily Sonestedt
  • Fonction : Auteur
Hanna Sartor
  • Fonction : Auteur
Domenico Palli
  • Fonction : Auteur
Ane Dorronsoro
  • Fonction : Auteur
Pilar Amiano
  • Fonction : Auteur
Malin Sund
Rosario Tumino
Elio Riboli

Résumé

Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

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Cancer
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Dates et versions

hal-04069321 , version 1 (18-04-2023)

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Sahar G. Yammine, Inge Huybrechts, Carine Biessy, Laure Dossus, Salvatore Panico, et al.. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition. BMC Cancer, 2023, 23 (1), ⟨10.1186/s12885-023-10611-0⟩. ⟨hal-04069321⟩
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