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Article Dans Une Revue Cancers Année : 2023

A Suggested Modification to FIGO Stage IV Epithelial Ovarian Cancer

Marie Métairie
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Jennifer Uzan
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Yohann Dabi
Cyril Touboul
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Résumé

International Federation of Gynecology and Obstetrics (FIGO) staging classification for stage IV epithelial ovarian cancer (EOC) separates stages IVA (pleural effusion) and IVB (parenchymal and/or extra-abdominal lymph node metastases). We aimed to evaluate its prognostic impact and to compare survival according to the initial metastatic location. We conducted a multicenter study between 2000 and 2020, including patients with a FIGO stage IV EOC. Primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS) and recurrence rates. We included 307 patients: 98 (32%) had FIGO stage IVA and 209 (68%) had FIGO stage IVB. The median OS and PFS of stage IVA patients were significantly lower than those of stage IVB patients (31 versus 45 months (p = 0.02) and 18 versus 25 months (p = 0.01), respectively). Recurrence rate was higher in stage IVA than IVB patients (65% versus 47% (p = 0.004)). Initial pleural involvement was a poor prognostic factor with a median OS of 35 months versus 49 months for patients without initial pleural involvement (p = 0.024). Patients with FIGO stage IVA had a worse prognosis than patients with FIGO stage IVB EOC. Pleural involvement appears to be relevant for predicting survival. We suggest a modification of the current FIGO staging classification.
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hal-04069350 , version 1 (14-04-2023)

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Marie Métairie, Louise Benoit, Meriem Koual, Enrica Bentivegna, Henri Wohrer, et al.. A Suggested Modification to FIGO Stage IV Epithelial Ovarian Cancer. Cancers, 2023, 15 (3), pp.706. ⟨10.3390/cancers15030706⟩. ⟨hal-04069350⟩
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