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Article Dans Une Revue Annals of Intensive Care Année : 2023

Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials

Jeanne Iachkine
  • Fonction : Auteur
Niccolò Buetti
  • Fonction : Auteur
Harm-Jan de Grooth
  • Fonction : Auteur
Anaïs Briant
  • Fonction : Auteur
Olivier Mimoz
  • Fonction : Auteur
Bruno Mégarbane
Jean-Paul Mira
  • Fonction : Auteur
Xavier Valette
  • Fonction : Auteur
Cédric Daubin
  • Fonction : Auteur
Damien Du Cheyron
  • Fonction : Auteur
Leonard Mermel
  • Fonction : Auteur

Résumé

Background The anatomic site for central venous catheter insertion influences the risk of central venous catheter-related intravascular complications. We developed and validated a predictive score of required catheter dwell time to identify critically ill patients at higher risk of intravascular complications.

Methods We retrospectively conducted a cohort study from three multicenter randomized controlled trials enrolling consecutive patients requiring central venous catheterization. The primary outcome was the required catheter dwell time, defined as the period between the first catheter insertion and removal of the last catheter for absence of utility. Predictors were identified in the training cohort (3SITES trial; 2336 patients) through multivariable analyses based on the subdistribution hazard function accounting for death as a competing event. Internal validation was performed in the training cohort by 500 bootstraps to derive the CVC-IN score from robust risk factors. External validation of the CVC-IN score were performed in the testing cohort (CLEAN, and DRESSING2; 2371 patients).

Results The analysis was restricted to patients requiring mechanical ventilation to comply with model assumptions. Immunosuppression (2 points), high creatinine > 100 micromol/L (2 points), use of vasopressor (1 point), obesity (1 point) and older age (40–59, 1 point; ≥ 60, 2 points) were independently associated with the required catheter dwell time. At day 28, area under the ROC curve for the CVC-IN score was 0.69, 95% confidence interval (CI) [0.66–0.72] in the training cohort and 0.64, 95% CI [0.61–0.66] in the testing cohort. Patients with a CVC-IN score ≥ 4 in the overall cohort had a median required catheter dwell time of 24 days (versus 11 days for CVC-IN score < 4 points). The positive predictive value of a CVC-IN score ≥ 4 was 76.9% for > 7 days required catheter dwell time in the testing cohort.

Conclusion The CVC-IN score, which can be used for the first catheter, had a modest ability to discriminate required catheter dwell time. Nevertheless, preference of the subclavian site may contribute to limit the risk of intravascular complications, in particular among ventilated patients with high CVC-IN score. Trials Registration NCT01479153, NCT01629550, NCT01189682

Dates et versions

hal-04087800 , version 1 (03-05-2023)

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Jeanne Iachkine, Niccolò Buetti, Harm-Jan de Grooth, Anaïs Briant, Olivier Mimoz, et al.. Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials. Annals of Intensive Care, 2023, 13 (1), pp.5. ⟨10.1186/s13613-023-01099-9⟩. ⟨hal-04087800⟩
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