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Article Dans Une Revue (Article De Synthèse) American Journal of Hematology Année : 2023

Complement biology for hematologists

Résumé

The complement system is part of the innate immunity. An increased activation or a loss of the regulation of this fine-tuned cascade is involved in a variety of hematological diseases. During the last decade, anti-C5 therapies have revolutionized the management and prognosis of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic and uremic syndrome (aHUS). The availability of a rapidly growing number of innovative complement inhibitors has opened new therapeutic perspectives for several other hematological disorders in which the complement is involved at different degrees. This review focuses on complement biology and its mechanisms of activation in hematological diseases.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-04088946 , version 1 (05-05-2023)
hal-04088946 , version 2 (10-05-2023)

Identifiants

Citer

Anna Duval, Véronique Frémeaux-Bacchi. Complement biology for hematologists. American Journal of Hematology, 2023, Complement Inhibition in Medicine: Hematology and Beyond, 98 (S4), pp.S5-S19. ⟨10.1002/ajh.26855⟩. ⟨hal-04088946v2⟩
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