The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER
Résumé
Highlights d The Get1/2 complex forms an aqueous channel in reconstituted lipid bilayers d The channel is composed of two Get1/2 heterodimers with a 2.5-nm-diameter pore d Get3 seals Get1/2 channels that dynamically open and close in the membrane d Get1/2 channel activity is required to release TA protein
Domaines
Biochimie, Biologie MoléculaireOrigine | Fichiers éditeurs autorisés sur une archive ouverte |
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