The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER - Université Paris Cité
Article Dans Une Revue Cell Reports Année : 2023

The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER

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Highlights d The Get1/2 complex forms an aqueous channel in reconstituted lipid bilayers d The channel is composed of two Get1/2 heterodimers with a 2.5-nm-diameter pore d Get3 seals Get1/2 channels that dynamically open and close in the membrane d Get1/2 channel activity is required to release TA protein
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hal-04116419 , version 1 (04-06-2023)

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Paul Heo, Jacob A Culver, Jennifer Miao, Frederic Pincet, Malaiyalam Mariappan. The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER. Cell Reports, 2023, 42 (1), pp.111921. ⟨10.1016/j.celrep.2022.111921⟩. ⟨hal-04116419⟩
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