Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Neuroscience Letters Année : 2003

Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.

Résumé

It has been reported that cocaine and amphetamine-regulated transcript (Cart) peptides can increase locomotor activity and produce a conditioned place preference. To establish whether or not Cart can be consider as a valuable marker of addiction we performed a comparative study of the expression of Cart and Fos genes by several drugs of abuse. This was achieved using real-time quantitative polymerase chain reaction in four rat brain structures: prefrontal cortex, caudate putamen, nucleus accumbens and hippocampus. As expected, a significant induction of the immediate early gene Fos was observed after acute administration of morphine, cocaine, 3, 4-methylenedioxymethamphetamine and Delta(9)-Tetrahydrocannabinol. On the contrary none of these drugs was able to produce a significant change in Cart mRNA levels demonstrating that the expression of this gene is not modulated by drugs of abuse in these brain structures.
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Dates et versions

inserm-00171266 , version 1 (13-09-2007)

Identifiants

  • HAL Id : inserm-00171266 , version 1
  • PUBMED : 12821175

Citer

Cynthia Marie-Claire, Ingrid Laurendeau, Corine Canestrelli, Cindie Courtin, Michel Vidaud, et al.. Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.. Neuroscience Letters, 2003, 345 (2), pp.77-80. ⟨inserm-00171266⟩
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