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Article Dans Une Revue Antioxidants and Redox Signaling Année : 2016

Imaging ROS-induced modifications in living systems 4 5

Résumé

Significance: Reactive Oxygen Species (ROS) mayregulatesignaling, ion channels, transcription factors and biosynthetic processes. ROS-related diseases can be either due to a shortage or to an excess of ROS. Recent advances: Since biological activity of ROSdepends on not only concentration but also spatial and temporal distribution, real-time imagingof ROS, possibly “invivo”, has be-come a need for scientists,with potential for clinical translation. New imaging techniques, as well as new contrast agents in clinically established modalities, was developed in the last decade. Critical issues: An ideal imaging technique should determine ROS changeswith high spatio-temporal resolution, detectphysiologically relevant variations in ROS concentration and provide specificity towards different redox couples. Furthermore, for invivoapplications, bioavailability of sensors, tissue penetrationand a highsignal-to-noise ratio are additional requirements to be satisfied. Future directions: None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform.
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Dates et versions

inserm-01313147 , version 1 (09-05-2016)

Identifiants

  • HAL Id : inserm-01313147 , version 1
  • PUBMED : 27139586

Citer

Giuseppe Maulucci, Goran Bačić, Lori Bridal, Harald Hhw Schmidt, Bertrand Tavitian, et al.. Imaging ROS-induced modifications in living systems 4 5. Antioxidants and Redox Signaling, 2016, 24 (16), pp.939-58. ⟨inserm-01313147⟩
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