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Article Dans Une Revue Brain imaging and behavior (Brain Imaging Behav) Année : 2014

The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson (1, 2) , Jason L. Stein (3) , Sarah Medland (4) , Derrek D Hibar (2) , Alejandro Arias Vasquez (5) , Miguel E. Renteria (4) , Roberto Toro (6) , Neda Jahanshad (2) , Gunter Schumann (7) , Barbara Franke (5) , Margaret J. Wright (4) , Nicholas G. Martin (4) , Ingrid Agartz (8, 9, 10) , Martin Alda (11) , Saud Alhusaini (12, 13) , Laura Almasy (14) , Jorge Almeida (11, 15) , Kathryn Alpert (16) , Nancy C. Andreasen (17) , Ole A. Andreassen (18, 19) , Liana G. Apostolova (3) , Katja Appel (20, 21) , Nicola J. Armstrong (22) , Benjamin Aribisala (23, 24) , Mark E. Bastin (23, 24) , Michael Bauer (25) , Carrie E. Bearden (26) , Ørjan Bergmann (27) , Elisabeth B. Binder (28) , John Blangero (14) , Henry J. Bockholt (17) , Erlend Bøen (27, 18) , Catherine Bois (29, 23) , Dorret I. Boomsma (30, 31) , Tom Booth (32) , Ian J. Bowman (2) , Janita Bralten (33, 5) , Rachel M. Brouwer (34, 35) , Han G. Brunner (5, 36) , David G. Brohawn (37, 38) , Randy L. Buckner (39, 40) , Jan Buitelaar (41, 33) , Kazima M Bulayeva (42, 43) , Juan R. Bustillo (44) , Vince D. Calhoun (45, 46) , Dara M. Cannon (47) , Rita M. Cantor (48, 49) , Melanie A. Carless (14) , Xavier Caseras (50) , Gianpiero L. Cavalleri (12) , M. Mallar Chakravarty (51, 52) , Kiki D. Chang (53) , Christopher R. K. Ching (2) , Andrea Christoforou (19, 54) , Sven Cichon (55, 56, 57) , Vincent P. Clark (44) , Patricia Conrod (7, 58) , Giovanni Coppola (26, 3) , Benedicto Crespo-Facorro (59, 60) , Joanne E Curran (14) , Michael Czisch (28) , Ian J. Deary (61) , Eco J. C. de Geus (30, 31) , Anouk den Braber (30) , Giuseppe Delvecchio (7) , Chantal Depondt (62) , Lieuwe de Haan (31) , Greig I. de Zubicaray (63) , Danai Dima (7) , Rali Dimitrova (29, 23) , Srdjan Djurovic (8, 19, 18) , Hongwei Dong (2) , Gary Donohoe (47, 64) , Ravindranath Duggirala (14) , Thomas D. Dyer (14) , Stefan Ehrlich (65, 66) , Carl Johan Ekman (9, 10) , Torbjørn Elvsåshagen (27, 18) , Louise Emsell (47) , Susanne Erk (67) , Thomas Espeseth (19) , Jesen Fagerness (65) , Scott Fears (26) , Iryna Fedko (30) , Guillén Fernández (33, 5) , Simon E. Fisher (33, 68) , Tatiana Foroud (69) , Peter T. Fox (70, 71) , Clyde Francks (68, 33) , Sophia D Frangou (72) , Eva Maria Frey (73) , Thomas Frodl (73, 64) , Vincent Frouin (74) , Hugh Garavan (75) , Sudheer Giddaluru (76, 54) , David C. Glahn (77, 78) , Beata Godlewska (79) , Rita Z. Goldstein (80) , Randy L. Gollub (81, 65) , Hans J. Grabe (20, 82, 83, 21) , Oliver Grimm (84) , Oliver Gruber (85) , Tulio Guadalupe (86, 68) , Raquel E. Gur (87) , Ruben C. Gur (87) , Harald H. H. Göring (14) , Saskia Hagenaars (29, 23) , Tomas Hajek (11) , Geoffrey B. Hall (88) , Jérémy Hall (23, 29) , John Hardy (89) , Catharina A. Hartman (90) , Johanna Hass (66) , Sean N. Hatton (91) , Unn K. Haukvik (92, 19) , Katrin Hegenscheid (20, 21) , Andreas Heinz (67) , Ian B. Hickie (91) , Beng-Choon Ho (17) , David Hoehn (28) , Pieter J. Hoekstra (90) , Marisa Hollinshead (38, 40) , Avram J. Holmes (38, 40) , Georg Homuth (20, 21) , Martine Hoogman (5) , L. Elliot Hong (93) , Norbert Hosten (20, 21) , Jouke-Jan Hottenga (30) , Hilleke E. Hulshoff Pol (34) , Kristy S. Hwang (94, 95) , Clifford R. Jack Jr (96) , Mark Jenkinson (97) , Caroline Johnston (7, 98) , Erik G. Jönsson (9, 10) , René S. Kahn (34, 35) , Dalia Kasperaviciute (89) , Sinead Kelly (99, 64) , Sungeun Kim (100) , Peter M. Kochunov (101) , Laura Koenders (31, 30) , Bernd Krämer (85) , John B. J. Kwok (102, 103) , Jim Lagopoulos (91) , Gonzalo Laje (104) , Mikael Landén (105, 106) , Bennett A. Landman (107) , John Lauriello (108) , Stephen M. Lawrie (29, 23) , Phil H. Lee (109, 38) , Stephanie Le Hellard (19, 54) , Hervé Lemaître (110, 111, 112, 113) , Cassandra D. Leonardo (2) , Chiang-Shan Li (114) , Benny Liberg (106) , David C. Liewald (61) , Xinmin Liu (115, 116) , Lorna M. Lopez (23) , Eva Loth (7) , Anbarasu Lourdusamy (117) , Michelle Luciano (23) , Fabio Macciardi (118, 119) , Marise W. J. Machielsen (31) , Glenda M. MacQueen (120, 121) , Ulrik F. Malt (18, 122) , René Mandl (34) , Dara S. Manoach (38) , Jean-Luc Martinot (123, 113, 111, 110) , Mar Matarin (89) , Karen Mather (124) , Manuel Mattheisen (125, 55, 126) , Morten Mattingsdal (19, 127) , Andreas Meyer-Lindenberg (128) , Colm McDonald (47) , Andrew McIntosh (23, 29) , Francis J. McMahon (115) , Katie L. McMahon (129, 130) , Eva Meisenzahl (131) , Ingrid Melle (19, 27) , Yuri Milaneschi (132, 31, 30) , Sebastian Mohnke (67) , Grant W. Montgomery (133) , Derek W. Morris (64) , Eric K. Moses (134, 14) , Bryon A. Mueller (135) , Susana Muñoz Maniega (23, 24) , Thomas W. Mühleisen (55, 56) , Bertram Müller-Myhsok (28, 136) , Benson Mwangi (137) , Matthias Nauck (20, 21) , Kwangsik Nho (138) , Thomas E. Nichols (139) , Lars-Göran Nilsson (140, 141) , Allison C. Nugent (115) , Lars Nyberg (142, 143) , Rene L. Olvera (144) , Jaap Oosterlaan (145, 30) , Roel A. Ophoff (146, 49, 34, 35) , Massimo Pandolfo (62) , Melina Papalampropoulou-Tsiridou (29, 23) , Martina Papmeyer (23, 29) , Tomas Paus (147, 148) , Zdenka Pausova (149) , Godfrey D. Pearlson (20, 114, 21) , Brenda W. Penninx (31, 30) , Charles P. Peterson (14) , Andrea Pfennig (25) , Mary Phillips (150, 151) , G. Bruce Pike (147, 121) , Jean-Baptiste Poline (152, 153) , Steven G. Potkin (154) , Benno Pütz (28) , Adaikalavan Ramasamy (155, 156, 157, 89) , Jerod Rasmussen (154) , Marcella Rietschel (128, 84) , Mark Rijpkema (33) , Shannon L. Risacher (100, 158) , Joshua L. Roffman (39) , Roberto Roiz-Santiañez (59, 60, 159) , Nina Romanczuk-Seiferth (67) , Emma J. Rose (160) , Natalie A. Royle (161, 24, 23) , Dan Rujescu (162) , Mina Ryten (163, 89, 164) , Perminder Sachdev (165, 102) , Alireza Salami (142, 143, 166) , Theodore D. Satterthwaite (87) , Jonathan Savitz (87, 167, 168) , Andrew J. Saykin (67) , Cathy Scanlon (47) , Lianne Schmaal (30) , Hugo G. Schnack (35) , Andrew J. Schork (169, 170) , S. Charles Schulz (171) , Remmelt Schür (35) , Larry Seidman (172, 173) , Li Shen (100) , Jody M. Shoemaker (45) , Andrew Simmons (7, 174, 175) , Sanjay Sisodiya (176) , Colin Smith (177, 23) , Jordan W. Smoller (178, 39, 109) , Jair C. Soares (137) , Scott R. Sponheim (179, 171) , Emma Sprooten (77) , John M. Starr (61, 23, 180) , Vidar M. Steen (54, 19) , Stephen Strakowski (181, 182) , Lachlan Strike (133) , Jessika Sussmann (29, 23) , Philipp G. Sämann (28) , Alexander Teumer (21) , Arthur W. Toga (1, 2) , Diana Tordesillas-Gutierrez (183, 60, 159, 59) , Daniah Trabzuni (157, 89, 184) , Sarah Trost (85) , Jessica Turner (185, 45) , Martijn D. van den Heuvel (35) , Nic J. van Der Wee (186, 187) , Kristel van Eijk (34, 35) , Theo G. M. van Erp (154) , Neeltje E. M. van Haren (35) , Dennis van’t Ent (188) , Marie-Jose van Tol (90) , Maria C. Valdés Hernández (23) , Dick J. Veltman (30) , Amelia Versace (151) , Henry Völzke (189, 20) , Robert Walker (190) , Henrik Walter (67, 191) , Lei Wang (16) , Joanna Wardlaw (23, 161) , Michael E. Weale (164) , Michael W. Weiner (192) , Wei Wen (124) , Lars T. Westlye (193, 19) , Heather C. Whalley (29, 194) , Christopher D. Whelan (12) , Tonya White (195) , Anderson M. Winkler (97, 114) , Katharina Wittfeld (82) , Girma Woldehawariat (115) , Christiane Wolf (28) , David Zilles (85) , Marcel P. Zwiers (33) , Anbupalam Thalamuthu (124) , Peter R. Schofield (103, 102) , Nelson B. Freimer (196, 49) , Natalia S. Lawrence (197) , Wayne Drevets (198)
1 LONI - Laboratory of Neuro Imaging [Los Angeles]
2 Keck School of Medicine [Los Angeles]
3 David Geffen School of Medicine [Los Angeles]
4 QIMR Berghofer Medical Research Institute
5 Radboud University Medical Center [Nijmegen]
6 Génétique Humaine et Fonctions Cognitives
7 Institute of Psychiatry, Psychology & Neuroscience, King's College London
8 UiO - University of Oslo
9 Department of Clinical Neurosciences, Neurology Division, Karolinska Institutet
10 Karolinska University Hospital [Stockholm]
11 Dalhousie University [Halifax]
12 RCSI - Royal College of Surgeons in Ireland
13 McGill University = Université McGill [Montréal, Canada]
14 Texas Biomedical Research Institute [San Antonio, TX]
15 University of Pittsburgh School of Medicine
16 Northwestern University [Chicago, Ill. USA]
17 University of Iowa [Iowa City]
18 Oslo University Hospital [Oslo]
19 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
20 Universität Greifswald - University of Greifswald
21 Interfaculty Institute for Genetics and Functional Genomics
22 School of Mathematics and Statistics
23 Edin. - University of Edinburgh
24 Brain Research Imaging Centre, Imaging Sciences
25 University Hospital Carl Gustav Carus [Dresden, Germany]
26 Semel Institute for Neuroscience and Human Behavior [Los Angeles, Ca]
27 Institute of Clinical Medicine [Oslo]
28 Max Planck Institute of Psychiatry
29 Royal Hospital for Sick Children [Edinburgh]
30 VU University Medical Center [Amsterdam]
31 Department of General Practice/EMGO Institute
32 CCACE - Centre for Cognitive Ageing and Cognitive Epidemiology
33 Donders Institute for Brain, Cognition and Behaviour
34 University Medical Center [Utrecht]
35 Brain Centre Rudolf Magnus [Utrecht]
36 Department of Human Genetics [Nijmegen]
37 Psychiatric and Neurodevelopmental Genetics Unit
38 Massachusetts General Hospital [Boston]
39 Department of Psychiatry [Boston]
40 Harvard University
41 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
42 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
43 RAS - Russian Academy of Sciences [Moscow]
44 The University of New Mexico [Albuquerque]
45 The Mind Research Network
46 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
47 NUI Galway - National University of Ireland [Galway]
48 Center for Neurobehavioral Genetics
49 UCLA - University of California [Los Angeles]
50 Institute of Psychological Medicine and Clinical Neurosciences
51 CAMH - Centre for Addiction and Mental Health [Toronto]
52 IBBME - Institute of Biomaterials and Biomedical Engineering [Toronto, ON, Canada]
53 Stanford School of Medicine [Stanford]
54 UiB - University of Bergen
55 Universität Bonn = University of Bonn
56 Jülich Research Centre
57 Unibas - Université de Bâle = University of Basel = Basel Universität
58 Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada]
59 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
60 IFIMAV - Fundación Marqués de Valdecilla-Instituto de Formación e Investigación Marqués de Valdecilla
61 Centre for Cognitive Ageing and Cognitive Epidemiology
62 ULB - Hôpital Erasme [Bruxelles]
63 School of Psychology, University of Queensland
64 Trinity College Dublin
65 MGH - Department of Psychiatry Massachusetts General Hospital
66 TU Dresden - Technische Universität Dresden = Dresden University of Technology
67 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
68 Max Planck Institute for Psycholinguistics
69 Department of Medical and Molecular Genetics
70 UTHealth - The University of Texas Health Science Center at Houston
71 South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
72 MSSM - Icahn School of Medicine at Mount Sinai [New York]
73 University Hospital Regensburg
74 NEUROSPIN - Service NEUROSPIN
75 University of Vermont [Burlington]
76 Haukeland University Hospital
77 Dpt of Psychiatry [New Haven]
78 Hartford Hospital
79 University of Oxford
80 Laboratory of Molecular Neuropsychiatry
81 Athinoula A. Martinos Center for Biomedical Imaging
82 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
83 HELIOS Klinikum Stralsund Hanseatic
84 University of Heidelberg, Medical Faculty
85 Georg-August-University = Georg-August-Universität Göttingen
86 IMPRS - International Max Planck Research School for Language Sciences
87 University of Pennsylvania
88 McMaster University [Hamilton, Ontario]
89 UCL Queen Square Institute of Neurology
90 UMCG - University Medical Center Groningen [Groningen]
91 Brain and Mind Research Institute
92 Diakonhjemmet Hospital
93 University of Maryland School of Medicine
94 Oakland University
95 University of Rochester School of Medicine
96 Mayo Clinic [Rochester]
97 FMRIB - Oxford Centre for Functional Magnetic Resonance Imaging of the Brain
98 South London and Maudsley NHS Foundation Trust
99 FIMM - Institute for Molecular Medicine Finland [Helsinki]
100 Indiana University School of Medicine
101 University of Maryland [Baltimore]
102 UNSW - University of New South Wales [Sydney]
103 NeuRA - Neuroscience Research Australia
104 UMBC - University of Maryland [Baltimore County]
105 GU - Göteborgs Universitet = University of Gothenburg
106 Karolinska Institutet [Stockholm]
107 Vanderbilt University [Nashville]
108 Mizzou - University of Missouri [Columbia]
109 BROAD INSTITUTE - Broad Institute of MIT and Harvard
110 UCP - Université de Cergy Pontoise
111 SHFJ - Service Hospitalier Frédéric Joliot
112 U1000 - Neuroimagerie en psychiatrie
113 SCLIN - Clinatec - Centre de recherche biomédicale Edmond J.Safra
114 Department of Neuroscience, Yale University School of Medicine
115 NIH - National Institutes of Health [Bethesda, MD, USA]
116 CUMC - Columbia University Medical Center
117 UON - University of Nottingham, UK
118 UC Irvine - University of California [Irvine]
119 UNIMI - Università degli Studi di Milano = University of Milan
120 Hotchkiss Brain Institute
121 University of Calgary
122 HiOA - Oslo and Akershus University College of Applied Sciences [Oslo]
123 U1000 - Neuroimagerie en psychiatrie
124 Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
125 Department of Genomics
126 Aarhus University [Aarhus]
127 Sorlandet Hospital HF
128 University Hospital Mannheim | Universitätsmedizin Mannheim
129 Centre for Advanced Imaging
130 CAI - Centre for Advanced Imaging [Brisbane]
131 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
132 Translational Gerontology Branch
133 Queensland Institute of Medical Research
134 UWA - The University of Western Australia
135 University of Minnesota [Morris]
136 SyNergy - Munich Cluster for systems neurology [Munich]
137 The University of Texas Medical School at Houston
138 Indiana State University
139 Department of Statistics [Warwick]
140 Stockholm Brain Institute [Stockholm, Sweden]
141 Stockholm University
142 Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden
143 Umeå University
144 University of Texas Health Science Center
145 Department of Clinical Neuropsychology
146 Center for Neurobehavioral Genetics
147 MNI - McConnell Brain Imaging Centre
148 RRI - Rotman Research Institute at the Baycrest Centre
149 SickKids - The Hospital for sick children [Toronto]
150 Department of Psychiatry
151 PITT - University of Pittsburgh
152 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data
153 UC Berkeley - University of California [Berkeley]
154 Department of Psychiatry and Human Behavior [Irvine]
155 Department of Medical and Molecular Genetics
156 Reta Lila Weston Institute, UCL Institute of Neurology
157 Department of Molecular Neuroscience
158 Indiana Alzheimer Disease Center
159 Universidad de Cantabria [Santander]
160 RTI International - Research Triangle Institute International
161 Centre for Cognitive Ageing and Cognitive Epidemiology
162 MLU - Martin-Luther-Universität Halle Wittenberg
163 Department of Medical and Molecular Genetics
164 King‘s College London
165 Prince of Wales Hospital
166 Karolinska Institute
167 Laureate institute for brain research, Tulsa
168 University of Tulsa
169 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
170 UC San Diego - University of California [San Diego]
171 University of Minnesota Medical School
172 BIDMC - Beth Israel Deaconess Medical Center [Boston]
173 HMS - Harvard Medical School [Boston]
174 Maudsley NHS Foundation Trust and Institute of Psychiatry
175 NIHR Biomedical Research Centre [London]
176 Institute of Neurology [London]
177 Edinburgh Dementia Prevention & Centre for Clinical Brain Sciences
178 Center for Human Genetic Research
179 VA NY Harbor Health Care System
180 Alzheimer Scotland Dementia Research Centre
181 Department of Psychiatry and Behavioral Neuroscience [UC, Cincinnati]
182 University of Cincinnati College of Medicine
183 Marqués de Valdecilla University Hospital [Santander]
184 KFSHRC - King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia]
185 Georgia State University
186 Psychiatry and Leiden Institute for Brain and Cognition
187 LUMC - Leiden University Medical Center
188 Department of Biological Psychology [Amsterdam]
189 Institute for Community Medicine
190 The Centre for Regenerative Medicine
191 Berlin School of Mind and Brain [Berlin]
192 UC San Francisco - University of California [San Francisco]
193 Department of Psychology [Oslo]
194 School of Chemistry, University of Edinburgh
195 Department of Public Health, Erasmus University Medical Centre, Rotterdam
196 Department of Psychiatry and Biobehavioral Sciences
197 University of Exeter
198 Janssen Research & Development
Roberto Toro
Martin Alda
  • Fonction : Auteur
  • PersonId : 945734
Elisabeth B. Binder
Vincent Frouin
Ian B. Hickie
  • Fonction : Auteur
  • PersonId : 941433
Bennett A. Landman
Sanjay Sisodiya
  • Fonction : Auteur
  • PersonId : 890022

Résumé

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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pasteur-01967166 , version 1 (30-12-2018)

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Paul M. Thompson, Jason L. Stein, Sarah Medland, Derrek D Hibar, Alejandro Arias Vasquez, et al.. The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data. Brain imaging and behavior (Brain Imaging Behav), 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩. ⟨pasteur-01967166⟩
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