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Article Dans Une Revue Nature Communications Année : 2022

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Luis Molinos-Albert (1) , Valerie Lorin (1) , Valérie Monceaux (2) , Sylvie Orr (3) , Asma Essat (3) , Jérémy Dufloo (4) , Olivier Schwartz (4) , Christine Rouzioux (5) , Laurence Meyer (3) , Laurent Hocqueloux (6) , Asier Sáez-Cirión (2) , Hugo Mouquet (1) , Anrs Visconti Study Group , Thierry Prazuck , Barbara De Dieuleveult , Firouzé Bani-Sadr (7) , Maxime Hentzien (7) , Jean-Luc Berger (7) , Isabelle Kmiec (7) , Gilles Pichancourt (8) , Safa Nasri (8) , Gilles Hittinger (9) , Véronique Lambry (9) , Anne-Cécile Beauey (9) , Gilles Pialoux (10) , Christia Palacios (10) , Martin Siguier (10) , Anne Adda (10) , Jane Foucoin (10) , Laurence Weiss (11) , Marina Karmochkine (11) , Mohamed Meghadecha (11) , Magali Ptak (11) , Dominique Salmon-Ceron (12) , Philippe Blanche (12) , Marie-Pierre Piétri (12) , Jean-Michel Molina (13) , Olivier Taulera (13) , Caroline Lascoux-Combe (13) , Diane Ponscarme (13) , Jeannine Delgado Bertaut (13) , Djamila Makhloufi (14) , Matthieu Godinot (14) , Valérie Artizzu (14) , Yazdan Yazdanpanah (15) , Sophie Matheron (15) , Cindy Godard (15) , Zélie Julia (15) , Louis Bernard (15) , Frédéric Bastides (16) , Olivier Bourgault (16) , Christine Jacomet (17) , Emilie Goncalves (17) , Agnès Meybeck (18) , Thomas Huleux (18) , Pauline Cornavin (18) , Yasmine Debab (19) , David Théron (19) , Patrick Miailhes (20) , Laurent Cotte (20) , Sophie Pailhes (20) , Stanislas Ogoudjobi (20) , Jean Paul Viard (21) , Marie-Josée Dulucq (21) , Loïc Bodard (22) , Francoise Churaqui (22) , Thomas Guimard (23) , Laetitia Laine (23)
Valerie Lorin
Jérémy Dufloo
Olivier Schwartz
Laurent Hocqueloux
Anrs Visconti Study Group
  • Fonction : Auteur
Thierry Prazuck
  • Fonction : Auteur
Barbara De Dieuleveult
  • Fonction : Auteur
Gilles Hittinger
  • Fonction : Auteur
Véronique Lambry
  • Fonction : Auteur
Gilles Pialoux
  • Fonction : Auteur
Martin Siguier
  • Fonction : Auteur
Anne Adda
  • Fonction : Auteur
Jane Foucoin
  • Fonction : Auteur

Résumé

HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.

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Virologie
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pasteur-03654232 , version 1 (28-04-2022)

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Luis Molinos-Albert, Valerie Lorin, Valérie Monceaux, Sylvie Orr, Asma Essat, et al.. Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers. Nature Communications, 2022, 13 (1), pp.1944. ⟨10.1038/s41467-022-29511-1⟩. ⟨pasteur-03654232⟩
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