Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors - Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 IRMAIC Access content directly
Journal Articles Healthcare Year : 2022

Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors

Abstract

Background: Cystic Fibrosis (CF) adult patients experience daily physical symptoms and disabilities that may impact their quality of life and mental health. Methods: This prospective study aimed to evaluate the relative contribution of the familial, occupational, and social environment, besides that of the main physical and mental health factors, to the quality of life of CF adult patients using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) in a multivariate model. Results: Fifty patients were analyzed (70% of men; median age of 25 years; median body mass index of 21 kg/m²; median FEV1 of 57%). Anxiety and depression scores were negatively associated with 9 of the 12 CFQ-R domains. When controlling for anxiety and depression, FEV1% and BMI were significant positive predictors of several domains of the CFQ-R. All the familial, occupational, and social components analyzed but one (professional training) were predictors of at least one domain of the CFQ-R. Conclusion: Anxiety and depression explained a greater proportion of the variance than physical variables (age, sex, BMI, FEV1%, and exacerbation in the last year) in CF HRQoL. Many familial, occupational, and social components were also specifically and independently predictors of some HRQoL domains. Their screening might help identifying CF patients eligible for specific interventions, focusing on the impaired QoL dimensions.
Fichier principal
Vignette du fichier
JulienAncel_healthcare_2022.pdf (287.54 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03800280 , version 1 (06-10-2022)

Licence

Attribution

Identifiers

Cite

Julien Ancel, Claire Launois, Jeanne-Marie Perotin, Bruno Ravoninjatovo, Pauline Mulette, et al.. Health-Related Quality of Life in Adults with Cystic Fibrosis: Familial, Occupational, Social, and Mental Health Predictors. Healthcare, 2022, 10 (7), pp.1351. ⟨10.3390/healthcare10071351⟩. ⟨hal-03800280⟩
35 View
53 Download

Altmetric

Share

Gmail Facebook X LinkedIn More