Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Journal of Experimental Medicine Année : 2007

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Shen-Ying Zhang
Huey-Hsuan Chang
  • Fonction : Auteur
Kun Yang
Maya Chrabieh
  • Fonction : Auteur
Andrew C Issekutz
  • Fonction : Auteur
Coleen K Cunningham
  • Fonction : Auteur
John Gallin
  • Fonction : Auteur
Steven M Holland
  • Fonction : Auteur
Chaim Roifman
  • Fonction : Auteur
Stephan Ehl
Joanne Smart
  • Fonction : Auteur
Mimi Tang
  • Fonction : Auteur
Franck J Barrat
  • Fonction : Auteur
Ofer Levy
  • Fonction : Auteur
Douglas Mcdonald
  • Fonction : Auteur
Noorbibi K Day-Good
  • Fonction : Auteur
Richard Miller
  • Fonction : Auteur
Hidetoshi Takada
  • Fonction : Auteur
Toshiro Hara
  • Fonction : Auteur
Sami Al-Hajjar
  • Fonction : Auteur
Abdulaziz Al-Ghonaium
  • Fonction : Auteur
David Speert
  • Fonction : Auteur
Damien Sanlaville
Xiaoxia Li
  • Fonction : Auteur
Frédéric Geissmann
  • Fonction : Auteur
László Maródi
  • Fonction : Auteur
Ben-Zion Garty
  • Fonction : Auteur
Helen Chapel
  • Fonction : Auteur
Carlos Rodriguez-Gallego
Xavier Bossuyt
  • Fonction : Auteur
Laurent Abel
Anne Puel

Résumé

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains largely unknown. We diagnosed up to 28 patients with IRAK-4 deficiency, tested blood TLR responses for individual leukocyte subsets, and TLR responses for multiple cytokines. The patients' peripheral blood mononuclear cells (PBMCs) did not induce the 11 non-IFN cytokines tested upon activation with TLR agonists other than the nonspecific TLR3 agonist poly(I:C). The patients' individual cell subsets from both myeloid (granulocytes, monocytes, monocyte-derived dendritic cells [MDDCs], myeloid DCs [MDCs], and plasmacytoid DCs) and lymphoid (B, T, and NK cells) lineages did not respond to the TLR agonists that stimulated control cells, with the exception of residual responses to poly(I:C) and lipopolysaccharide in MDCs and MDDCs. Most patients (22 out of 28; 79%) suffered from invasive pneumococcal disease, which was often recurrent (13 out of 22; 59%). Other infections were rare, with the exception of severe staphylococcal disease (9 out of 28; 32%). Almost half of the patients died (12 out of 28; 43%). No death and no invasive infection occurred in patients older than 8 and 14 yr, respectively. The IRAK-4-dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae. Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria.

Domaines

Immunologie

Dates et versions

hal-00297302 , version 1 (15-07-2008)

Identifiants

Citer

Cheng-Lung Ku, Horst von Bernuth, Capucine Picard, Shen-Ying Zhang, Huey-Hsuan Chang, et al.. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.. Journal of Experimental Medicine, 2007, 204 (10), pp.2407-22. ⟨10.1084/jem.20070628⟩. ⟨hal-00297302⟩

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