Arginine behaviour after arginine or citrulline administration in older subjects
Résumé
Arginine (ARG) and its precursor citrulline (CIT) are popular dietary supplements, especially for the elderly. However, age-related reductions in lean body mass and alterations in organ functions could change their bioavailability. Pharmacokinetics and tolerance to amino acid (AA) loads are poorly documented in elderly subjects. The objective here was to characterise the plasma kinetics of CIT and ARG in a single-dosing study design. Eight fasting elderly men underwent two separate isomolar oral loading tests (10 g of CIT or 994 g of ARG). Blood was withdrawn over an 8-h period to measure plasma AA concentrations. Only CIT, ornithine and ARG plasma concentrations were changed. Volume of distribution was not dependent on AA administered. Conversely, parameters related to ARG kinetics were strongly dependent on AA administered: after ARG load, elimination was higher (ARG>CIT; P=0041) and admission period+time at peak concentration was lower (ARG
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Soumis le : mardi 26 septembre 2017-20:58:42
Dernière modification le : jeudi 14 décembre 2023-13:50:38
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Identifiants
- HAL Id : hal-01594605 , version 1
- DOI : 10.1017/s0007114515004638
- PRODINRA : 352090
- PUBMED : 26619904
- WOS : 000372633100003
Citer
Christophe Moinard, J. Maccario, Stephane Walrand, Virginie Lasserre, J. Marc, et al.. Arginine behaviour after arginine or citrulline administration in older subjects. British Journal of Nutrition, 2016, 115 (3), pp.399-404. ⟨10.1017/s0007114515004638⟩. ⟨hal-01594605⟩
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