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Article Dans Une Revue Nature Immunology Année : 2015

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

Résumé

Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.
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hal-01604354 , version 1 (02-10-2017)

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Cornelia Lindner, Irene Thomsen, Benjamin Wahl, Milas Ugur, Maya K Sethi, et al.. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nature Immunology, 2015, 16 (8), pp.880-888. ⟨10.1038/ni.3213⟩. ⟨hal-01604354⟩

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