Integrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project
Marta Benet
(1, 2)
,
Richard Albang
(3)
,
Mariona Pinart
(1, 2)
,
Cynthia Hohmann
(4)
,
Christina Tischer
(1, 2)
,
Isabella Annesi-Maesano
(5, 6, 7)
,
Nour Baïz
(5, 6, 7)
,
Carsten Bindslev-Jensen
,
Karin C. Lodrup Carlsen
(8, 9)
,
Kai-Håkon Carlsen
(8, 9)
,
Lourdes Cirugeda
(1, 2)
,
Esben Eller
,
Maria Pia Fantini
(10)
,
Ulrike Gehring
(11)
,
Beatrix Gerhard
(3)
,
Davide Gori
(10)
,
Eva Hallner
(12, 13)
,
Inger Kull
(12)
,
Jacopo Lenzi
(10)
,
Rosemary Mceachan
,
Eleonora Minina
(3)
,
Isabelle Momas
(14, 15, 16, 17)
,
Silvia Narduzzi
,
Emily Petherick
(18)
,
Daniela Porta
,
Fanny Rancière
(16, 14, 15)
,
Marie Standl
,
Maties Torrent
,
Alet Wijga
(19)
,
John Wright
,
Manolis Kogevinas
(1, 2)
,
Stefano Guerra
(1, 2, 20)
,
Jordi Sunyer
(1, 2)
,
Thomas Keil
(4)
,
Jean Bousquet
(21)
,
Dieter Maier
(3)
,
Josep M Antó
(1, 2)
,
Judith Garcia-Aymerich
(1, 2)
1
ISGlobal -
Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Biomax Informatics [Planegg]
4 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 INSERM - Institut National de la Santé et de la Recherche Médicale
7 UPMC - Université Pierre et Marie Curie - Paris 6
8 UiO - University of Oslo
9 Oslo University Hospital [Oslo]
10 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
11 Universiteit Utrecht / Utrecht University [Utrecht]
12 Karolinska Institutet [Stockholm]
13 Stockholm County Council
14 USPC - Université Sorbonne Paris Cité
15 EA 4064 - Epidémiologie Environnementale : Impact Sanitaire des Pollutions
16 UPD5 - Université Paris Descartes - Paris 5
17 DASES - Direction de l'Action Sociale de l'Enfance et de la Santé
18 Loughborough University
19 RIVM - National Institute for Public Health and the Environment [Bilthoven]
20 University of Arizona
21 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Biomax Informatics [Planegg]
4 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 INSERM - Institut National de la Santé et de la Recherche Médicale
7 UPMC - Université Pierre et Marie Curie - Paris 6
8 UiO - University of Oslo
9 Oslo University Hospital [Oslo]
10 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
11 Universiteit Utrecht / Utrecht University [Utrecht]
12 Karolinska Institutet [Stockholm]
13 Stockholm County Council
14 USPC - Université Sorbonne Paris Cité
15 EA 4064 - Epidémiologie Environnementale : Impact Sanitaire des Pollutions
16 UPD5 - Université Paris Descartes - Paris 5
17 DASES - Direction de l'Action Sociale de l'Enfance et de la Santé
18 Loughborough University
19 RIVM - National Institute for Public Health and the Environment [Bilthoven]
20 University of Arizona
21 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
Mariona Pinart
- Fonction : Auteur
- PersonId : 784478
- ORCID : 0000-0002-8223-1325
Cynthia Hohmann
- Fonction : Auteur
- PersonId : 936561
Christina Tischer
- Fonction : Auteur
- PersonId : 936564
Isabella Annesi-Maesano
- Fonction : Auteur
- PersonId : 754596
- IdHAL : isabella-annesi-maesano
- ORCID : 0000-0002-6340-9300
- IdRef : 123241847
Carsten Bindslev-Jensen
- Fonction : Auteur
- PersonId : 786713
- ORCID : 0000-0002-8940-038X
Esben Eller
- Fonction : Auteur
Ulrike Gehring
- Fonction : Auteur
- PersonId : 762120
- ORCID : 0000-0003-3612-5780
- IdRef : 10646633X
Rosemary Mceachan
- Fonction : Auteur
Silvia Narduzzi
- Fonction : Auteur
Daniela Porta
- Fonction : Auteur
Fanny Rancière
- Fonction : Auteur
- PersonId : 1031703
Marie Standl
- Fonction : Auteur
- PersonId : 791411
- ORCID : 0000-0002-5345-2049
Maties Torrent
- Fonction : Auteur
John Wright
- Fonction : Auteur
Manolis Kogevinas
- Fonction : Auteur
- PersonId : 762958
- ORCID : 0000-0002-9605-0461
Jean Bousquet
- Fonction : Auteur
- PersonId : 757330
- ORCID : 0000-0002-4061-4766
Josep M Antó
- Fonction : Auteur
- PersonId : 924699
Judith Garcia-Aymerich
- Fonction : Auteur
- PersonId : 766819
- ORCID : 0000-0002-7097-4586
- IdRef : 184015847
Résumé
The numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.