A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2014

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

1 USC - University of Southern California
2 IARC - International Agency for Research on Cancer
3 Institute of Genetics and Molecular Medicine
4 Cedars-Sinai Medical Center
5 University Medical Centre Groningen
6 Statens seruminstitut
7 Karolinska Institutet [Stockholm]
8 Karolinska University Hospital-Huddinge, Karolinska Institute
9 Cancer Prevention Institute of California
10 St Jude Children's Research Hospital
11 UCBL - Université Claude Bernard Lyon 1
12 University of Freiburg [Freiburg]
13 Bellvitge Biomedical Research Institute
14 University of York
15 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
16 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
17 MMCI - Masaryk Memorial Cancer Institute
18 City of Hope National Medical Center
19 Uppsala University
20 DCU - Dublin City University [Dublin]
21 MSSM - Icahn School of Medicine at Mount Sinai [New York]
22 Carver College of Medicine, University of Iowa
23 Radboud University [Nijmegen]
24 Mayo Clinic
25 University of Texas
26 CRESS (U1153 / UMR_A_1125 / UMR_S_1153) - Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité
27 NTNU - Norwegian University of Science and Technology
28 University of Glasgow
29 Tokyo Medical and Dental University
30 Clarient Pathology Services
31 Genome Québec
32 UniCa - Università degli Studi di Cagliari = University of Cagliari
33 University of Chicago
34 Harvard University
35 School of Cancer Sciences
36 Centre for Virus Research
T. Lightfoot
  • Fonction : Auteur
E. Roman
  • Fonction : Auteur
B. Glimelius
  • Fonction : Auteur
S. M. Ansell
  • Fonction : Auteur
L. C. Strong
  • Fonction : Auteur
T. M. Habermann
  • Fonction : Auteur
A. Lake
  • Fonction : Auteur
Y. Liu
  • Fonction : Auteur
  • PersonId : 4334
  • IdHAL : yi-liu
M. Lathrop
  • Fonction : Auteur
T. Best
  • Fonction : Auteur
A. D. Skol
  • Fonction : Auteur
M. Melbye
  • Fonction : Auteur
J. R. Cerhan
  • Fonction : Auteur
S. L. Slager
  • Fonction : Auteur
K. Onel
  • Fonction : Auteur

Résumé

Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR) = 0.81, 95% confidence interval (95% CI) = 0.76-0.86, P-combined 3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
Fichier principal
Vignette du fichier
2014_Cozen_Nature Communications_1.pdf (700.17 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02632096 , version 1 (27-05-2020)

Licence

Paternité

Identifiants

Citer

W. Cozen, M. N. Timofeeva, D. Li, A. Diepstra, D. Hazelett, et al.. A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications, 2014, 5, ⟨10.1038/ncomms4856⟩. ⟨hal-02632096⟩
14 Consultations
21 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More