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Article Dans Une Revue Nature Genetics Année : 2013

A variant in FTO shows association with melanoma risk not due to BMI

Mark M. Iles (1) , Matthew H. Law (2) , Simon N. Stacey (3) , Jiali Han (4, 5) , Shenying Fang (6) , Ruth Pfeiffer (7) , Mark Harland (8) , Stuart Macgregor (2) , John C. Taylor (8) , Katja K. Aben (9, 10) , Lars A. Akslen (11, 1) , Marie-Françoise Avril (12) , Esther Azizi (13) , Bert Bakker (14) , Kristrun R. Benediktsdottir (15, 16) , Wilma Bergman (14) , Giovanna Bianchi Scarra (17, 18) , Kevin M. Brown (19) , Donato Calista (20) , Valérie Chaudru (21, 22) , Maria Concetta Fargnoli (23) , Anne E. Cust (24) , Florence Demenais (22, 25) , Anne C. De Waal (26) , Tadeusz Dębniak (27) , David E. Elder (28) , Eitan Friedman (13) , Pilar Galan (29) , Paola Ghiorzo (17, 30) , Elizabeth M. Gillanders (7) , Alisa M. Goldstein (7) , Nelleke A. Gruis (14) , Johan Hansson (31) , Per Helsing (32) , Marko Hočevar (33) , Veronica Hoiom (31) , John L. Hopper (34) , Christian Ingvar (35) , Marjolein Janssen (36) , Mark A. Jenkins (34) , Peter A. Kanetsky (37) , Lambertus A. Kiemeney (10) , Julie Lang (38) , G. Mark Lathrop (22, 39) , Sancy Leachman (40) , Jeffrey E. Lee (6) , Jan Lubinski (27) , Rona M. Mackie (41) , Graham J. Mann (24, 42) , Nicholas G. Martin (2) , Jose I. Mayordomo (43) , Anders Molven (11, 1) , Suzanne Mulder (36) , Eduardo Nagore (44) , Srdjan Novakovic (33) , Ichiro Okamoto (45) , Jon H. Olafsson (15) , Haan Olsson (46) , Hubert Pehamberger (47) , Ketty Peris (23) , Maria Pilar Grasa (43) , Dolores Planelles (47) , Susana Puig (48, 49) , Joan Anton Puig-Butille (50, 49) , Juliette Randerson-Moor (8) , Celia Requena (44) , Licia Rivoltini (51) , Monica Rodolfo (51) , Mario Santinami (51) , Bardur Sigurgeirsson (15) , Helen Snowden (8) , Fengju Song (52, 53) , Patrick Sulem (3) , Kristin Thorisdottir (15) , Rainer Tuominen (31) , Patricia van Belle (37) , Nienke van Der Stoep (54) , Michelle M. van Rossum (10) , Qingyi Wei (55) , Judith Wendt (45) , Diana Zelenika (39) , Mingfeng Zhang , Maria Teresa Landi , Gudrnar Thorleifsson (3) , D. Timothy Bishop (8) , Christopher I. Amos , Nicholas K. Hayward (2) , Kari Stefansson (3, 15) , Julia A. Newton Bishop (8) , Jennifer H. Barrett (8)
1 Haukeland University Hospital
2 Queensland Institute of Medical Research
3 deCODE genetics [Reykjavik]
4 Harvard University
5 Brigham and Women's Hospital [Boston]
6 University of Texas Medical Branch
7 National Cancer Institute
8 St. James's University Hospital
9 Ctr Comprehens Canc
10 Radboud University [Nijmegen]
11 UiB - University of Bergen
12 UPD5 - Université Paris Descartes - Paris 5
13 TAU - Tel Aviv University
14 Universiteit Leiden = Leiden University
15 University of Iceland [Reykjavik]
16 Landspitali National University Hospital of Iceland
17 UniGe - Università degli studi di Genova = University of Genoa
18 San Martino Ist Sci Tumori
19 NCI
20 Maurizio Bufalini Hospital = Ospedale “M. Bufalini” di Cesena
21 UEVE - Université d'Évry-Val-d'Essonne
22 CEPH - Centre d'Etude du Polymorphisme Humain
23 UNIVAQ - Università degli Studi dell'Aquila = University of L'Aquila
24 University of Sydney
25 Sorbonne Paris Cite
26 Radboud University Medical Center [Nijmegen]
27 Pomeranian Med Univ
28 PennState University
29 UREN - Unité de Recherche en Epidémiologie Nutritionnelle
30 San Martino Ist Sci Tumori, Ist Ricovero & Cura Carattere Sci
31 Karolinska University Hospital [Stockholm]
32 UiO - University of Oslo
33 Institute of Oncology [Ljubljana]
34 University of Melbourne
35 Dept Surg
36 ServiceXS BV
37 Penn State - Pennsylvania State University
38 University of Glasgow
39 Ctr Natl Genotypage
40 USU - Utah State University
41 Dept Publ Hlth
42 New South Wales Government
43 University of Zaragoza - Universidad de Zaragoza [Zaragoza]
44 Instituto Valenciano de Oncologia
45 Medizinische Universität Wien = Medical University of Vienna
46 Skane University Hospital [Lund]
47 Ctr Blood Transfus, Lab Histocompatibil Mol Biol
48 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
49 ISC - Instituto de Salud Carlos III [Madrid]
50 University of Barcelona
51 IRCCS - Istituto di Ricovero e Cura a Carattere Scientifico
52 Brigham and Women’s Hospital [Boston, MA]
53 Tianjin Medical University Cancer Institute and Hospital
54 LUMC - Leiden University Medical Center
55 University of Texas
Mark M. Iles
  • Fonction : Auteur
  • PersonId : 1071406
Esther Azizi
  • Fonction : Auteur
Bert Bakker
Kevin M. Brown
  • Fonction : Auteur
NCI
Per Helsing
  • Fonction : Auteur
Christian Ingvar
  • Fonction : Auteur
Marjolein Janssen
  • Fonction : Auteur
Julie Lang
  • Fonction : Auteur
Jan Lubinski
  • Fonction : Auteur
Rona M. Mackie
  • Fonction : Auteur
Suzanne Mulder
  • Fonction : Auteur
Qingyi Wei
  • Fonction : Auteur
Mingfeng Zhang
  • Fonction : Auteur
Maria Teresa Landi
  • Fonction : Auteur
Christopher I. Amos
  • Fonction : Auteur

Résumé

We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

Dates et versions

hal-02645000 , version 1 (29-05-2020)

Identifiants

Citer

Mark M. Iles, Matthew H. Law, Simon N. Stacey, Jiali Han, Shenying Fang, et al.. A variant in FTO shows association with melanoma risk not due to BMI. Nature Genetics, 2013, 45 (4), pp.428 - 432. ⟨10.1038/ng.2571⟩. ⟨hal-02645000⟩
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