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Journal Articles Cancers Year : 2021

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

Swathi Kaliki
Xunda Ji
  • Function : Author
Yihua Zou
  • Function : Author
Riffat Rashid
  • Function : Author
Sadia Sultana
  • Function : Author
Sadik Taju Sherief
  • Function : Author
Rosdali Y. Diaz Coronado
  • Function : Author
Juan Luis Garcia Leon
  • Function : Author
Arturo Manuel Zapata López
  • Function : Author
Vladimir Polyakov
  • Function : Author
Tatiana Ushakova
  • Function : Author
Soma Rani Roy
  • Function : Author
Alia Ahmad
  • Function : Author
Lamis Al Harby
  • Function : Author
M. Ashwin Reddy
  • Function : Author
Mandeep Sagoo
  • Function : Author
Jesse L. Berry
  • Function : Author
Jonathan Kim
  • Function : Author
Ashley Polski
  • Function : Author
Nicholas Astbury
  • Function : Author
Covadonga Bascaran
  • Function : Author
Sharon Blum
  • Function : Author
Richard Bowman
  • Function : Author
Matthew Burton
  • Function : Author
Allen Foster
  • Function : Author
Nir Gomel
  • Function : Author
Naama Keren-Froim
  • Function : Author
Shiran Madgar
  • Function : Author
Andrew W. Stacey
  • Function : Author
David M. Steinberg
  • Function : Author
Ashik Mohamed
  • Function : Author
Marcia Zondervan
  • Function : Author
Ido Didi Fabian
  • Function : Author

Abstract

Background: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes. Methods: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. Results: The following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (p = 0.001), distance from home to nearest primary healthcare centre (p = 0.03) and mean lag time between detection of first symptom to visit to RB treatment centre (p = 0.0007). After adjusting for country income, increased lag time between onset of symptoms and diagnosis of RB was associated with higher chances of an advanced tumour at presentation (p < 0.001), higher chances of high-risk histopathology features (p = 0.003), regional lymph node metastasis (p < 0.001), systemic metastasis (p < 0.001) and death (p < 0.001). Conclusions: There is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes.

Dates and versions

hal-03239898 , version 1 (27-05-2021)

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Swathi Kaliki, Xunda Ji, Yihua Zou, Riffat Rashid, Sadia Sultana, et al.. Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries. Cancers, 2021, 13 (8), pp.1956. ⟨10.3390/cancers13081956⟩. ⟨hal-03239898⟩

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