Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats. - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue eLife Année : 2021

Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats.

Résumé

Delineating the decision-making mechanisms underlying choice between drug and nondrug rewards remains a challenge. This study adopts an original approach to probe these mechanisms by comparing response latencies during sampling versus choice trials. While lengthening of latencies during choice is predicted in a deliberative choice model (DCM), the race-like response competition mechanism postulated by the Sequential choice model (SCM) predicts a shortening of latencies during choice compared to sampling. Here, we tested these predictions by conducting a retrospective analysis of cocaine-versus-saccharin choice experiments conducted in our laboratory. We found that rats engage deliberative decision-making mechanisms after limited training, but adopt a SCM-like response selection mechanism after more extended training, while their behavior is presumably habitual. Thus, the DCM and SCM may not be general models of choice, as initially formulated, but could be dynamically engaged to control choice behavior across early and extended training.
Fichier principal
Vignette du fichier
Vandaele 2021 article.pdf (1.26 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03368485 , version 1 (06-10-2021)

Identifiants

Citer

Youna Vandaele, Magalie Lenoir, Caroline Vouillac-Mendoza, Karine Guillem, Serge H. Ahmed. Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats.. eLife, 2021, 10, ⟨10.7554/eLife.64993⟩. ⟨hal-03368485⟩
15 Consultations
28 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More