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Article Dans Une Revue Journal of Affective Disorders Année : 2019

FKBP5 gene variants and borderline personality disorder

Résumé

Background Genes associated with the physiological response to stress in the hypothalamic-pituitary-adrenal axis are considered as good candidates for genetic research in borderline personality disorder (BPD). Methods In this study, five FKBP5 (a co-chaperone of the glucocorticoid receptor) SNPs (rs3800373, rs9296158, rs737054, rs1360780, rs9470080) were genotyped in a sample of 101 unrelated Caucasian patients with BPD and 111 ethnically matched healthy controls. The interaction between FKBP5 polymorphisms and childhood trauma was also tested. Results All FKBP5 polymorphisms genotyped showed significant associations with BPD. A main effect of rs9470080 (p = 0.01) and gene x environment (physical abuse) interaction (p = 0.01) was found. A gene x environment (emotional abuse) interaction was also found for rs3800373 (p = 0.03). However, these interactions did not remain significant after multiple testing corrections. Limitations In this study, only 5 genetic variants were tested and thus tagging of the FKBP5 gene was incomplete. Moreover, the sample size is moderate. Conclusion BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.
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hal-03485691 , version 1 (20-12-2021)

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Paternité - Pas d'utilisation commerciale

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Ali Amad, Nicolas Ramoz, Hugo Peyre, Pierre Thomas, Philip Gorwood. FKBP5 gene variants and borderline personality disorder. Journal of Affective Disorders, 2019, 248, pp.26 - 28. ⟨10.1016/j.jad.2019.01.025⟩. ⟨hal-03485691⟩
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