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Article Dans Une Revue Neuron Année : 2023

Inhibitory top-down projections from zona incerta mediate neocortical memory

Résumé

Top-down projections convey a family of signals encoding previous experiences and current aims to the sensory neocortex, where they converge with external bottom-up information to enable perception and memory. Whereas top-down control has been attributed to excitatory pathways, the existence, connectivity, and information content of inhibitory top-down projections remain elusive. Here, we combine synaptic two-photon calcium imaging, circuit mapping, cortex-dependent learning, and chemogenetics in mice to identify GABAergic afferents from the subthalamic zona incerta as a major source of top-down input to the neocortex. Incertocortical transmission undergoes robust plasticity during learning that improves information transfer and mediates behavioral memory. Unlike excitatory pathways, incertocortical afferents form a disinhibitory circuit that encodes learned top-down relevance in a bidirectional manner where the rapid appearance of negative responses serves as the main driver of changes in stimulus representation. Our results therefore reveal the distinctive contribution of long-range (dis)inhibitory afferents to the computational flexibility of neocortical circuits.
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hal-04092133 , version 1 (09-05-2023)

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Anna Schroeder, M. Belén Pardi, Joram Keijser, Tamas Dalmay, Ayelén Groisman, et al.. Inhibitory top-down projections from zona incerta mediate neocortical memory. Neuron, 2023, 111 (5), pp.727-738.e8. ⟨10.1016/j.neuron.2022.12.010⟩. ⟨hal-04092133⟩

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