Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2023

Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study

Floran Begue
  • Fonction : Auteur
Kévin Chemello
  • Fonction : Auteur
Bryan Veeren
Brice Lortat-Jacob
Nathalie Zappella
  • Fonction : Auteur
Aurelie Snauwaert
  • Fonction : Auteur
Tiphaine Robert
  • Fonction : Auteur
Philippe Rondeau
Marie Lagrange-Xelot
  • Fonction : Auteur
Philippe Montravers
David Couret
Sébastien Tanaka

Résumé

SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of apolipoprotein levels during COVID-19 is not well described and understood. The objective of our study is to measure plasma levels of 14 apolipoproteins in patients with COVID-19 and to evaluate the relationships between apolipoprotein levels, severity factors and patient outcomes. From November to March 2021, 44 patients were recruited on admission to the intensive care unit because of COVID-19. Fourteen apolipoproteins and LCAT were measured by LC-MS/MS in plasma of 44 COVID-19 patients on admission to the ICU and 44 healthy control subjects. Absolute apolipoprotein concentrations were compared between COVID-19 patients and controls. Plasma apolipoproteins (Apo) A (I, II, IV), C(I, II), D, H, J and M and LCAT were lower in COVID-19 patients, whereas Apo E was higher. COVID-19 severity factors such as PaO2/FiO2 ratio, SO-FA score and CRP were correlated with certain apolipoproteins. Lower Apo B100 and LCAT levels were observed in non-survivors of COVID-19 versus survivors. To conclude, in this study, lipid and apolipoprotein profiles are altered in COVID-19 patients. Low Apo B100 and LCAT levels may be predictive of non-survival in COVID-19 patients.

Dates et versions

hal-04092218 , version 1 (09-05-2023)

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Citer

Floran Begue, Kévin Chemello, Bryan Veeren, Brice Lortat-Jacob, Alexy Tran-Dinh, et al.. Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study. International Journal of Molecular Sciences, 2023, 24 (5), pp.4605. ⟨10.3390/ijms24054605⟩. ⟨hal-04092218⟩
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