Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment - Université Paris Cité Accéder directement au contenu
Article Dans Une Revue Nutrients Année : 2023

Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment

Anne-Laure Couderc
Evelyne Liuu
Maxime Frelaut
  • Fonction : Auteur
Coline Montégut
  • Fonction : Auteur
Soraya Mebarki
  • Fonction : Auteur
Romain Geiss
  • Fonction : Auteur
Zoé Ap Thomas
Aurélien Noret
  • Fonction : Auteur
Monica Pierro
Capucine Baldini
Frédéric Pamoukdjian

Résumé

This study will address the prevalence of pre-therapeutic sarcopenia (PS) and its clinical impact during cancer treatment among adult cancer patients ≥ 18 years of age. A meta-analysis (MA) with random-effect models was performed via a MEDLINE systematic review, according to the PRISMA statement, focusing on articles published before February 2022 that reported observational studies and clinical trials on the prevalence of PS and the following outcomes: overall survival (OS), progression-free survival (PFS), post-operative complications (POC), toxicities (TOX), and nosocomial infections (NI). A total of 65,936 patients (mean age: 45.7-85 y) with various cancer sites and extensions and various treatment modes were included. Mainly defined by CT scan-based loss of muscle mass only, the pooled prevalence of PS was 38.0%. The pooled relative risks were 1.97, 1.76, 2.70, 1.47, and 1.76 for OS, PFS, POC, TOX, and NI, respectively (moderate-to-high heterogeneity, I 2 : 58-85%). Consensus-based algorithm definitions of sarcopenia, integrating low muscle mass and low levels of muscular strength and/or physical performance, lowered the prevalence (22%) and heterogeneity (I 2 < 50%). They also increased the predictive values with RRs ranging from 2.31 (OS) to 3.52 (POC). PS among cancer patients is prevalent and strongly associated with poor outcomes during cancer treatment, especially when considering a consensus-based algorithm approach.
Fichier principal
Vignette du fichier
nutrients-15-01193.pdf (6.98 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04092423 , version 1 (09-05-2023)

Licence

Paternité

Identifiants

Citer

Anne-Laure Couderc, Evelyne Liuu, Pascaline Boudou-Rouquette, Johanne Poisson, Maxime Frelaut, et al.. Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment. Nutrients, 2023, 15 (5), pp.1193. ⟨10.3390/nu15051193⟩. ⟨hal-04092423⟩
5 Consultations
9 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More