Visible light amination/Smiles cascade: access to phthalazine derivatives - Université Paris Cité Access content directly
Journal Articles Chemical Science Year : 2016

Visible light amination/Smiles cascade: access to phthalazine derivatives

Abstract

We report the synthesis of various phthalazines via a new cascade reaction, initiated by visible light photocatalysis, involving a radical hydroamination reaction followed by a radical Smiles rearrangement. Phthalazine derivatives are obtained in high yields and from a broad scope readily accessible ortho-alkynylsulfonohydrazone precursors. The mild photoredox conditions ensure an excellent functional group tolerance. Application of this strategy to a one-pot protocol starting from the corresponding carbonyl compounds, and subsequent functionalization allow the rapid synthesis of structurally diverse structures.
Fichier principal
Vignette du fichier
c6sc01095d.pdf (963.78 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02384218 , version 1 (28-11-2019)

Identifiers

Cite

Etienne Brachet, Leyre Marzo, Mohamed Selkti, Burkhard König, Philippe Belmont. Visible light amination/Smiles cascade: access to phthalazine derivatives. Chemical Science, 2016, 7 (8), pp.5002-5006. ⟨10.1039/C6SC01095D⟩. ⟨hal-02384218⟩

Collections

CNRS INC-CNRS USPC
31 View
71 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More